![]() Recent surgery at sites where haemorrhage would be an especial risk. Patients predisposed to active bleeding including thrombocytopenia, peptic ulcer disease, cerebrovascular disorders, haemorrhagic blood disorders, bacterial endocarditis, severe hypertension, oesophageal varices.Potentially Fatal: Heparin-induced thrombocytopenia with or without thrombosis bleeding.Hypersensitivity reactions include urticaria, conjunctivitis, rhinitis, asthma, angioedema and anaphylactic shock. Slight fever, headache, chills, nausea, vomiting, constipation, epistaxis, bruising, slight haematuria, skin necrosis (SC inj), osteoporosis, alopecia.Unlabeled uses: Adjunct in therapy of coronary occlusion with acute MI, prevention of left ventricular thrombi and CVA post-MI, prevention of cerebral thrombosis in the evolving CVA.Prevention of clotting in blood samples and heparin lock sets and during dialysis procedures.Treatment of atrial fibrillation with embolization.Prevention and treatment of venous thrombosis and pulmonary embolism.It may reduce the activity of ATIII at very high doses. This inhibits the conversion of prothrombin to thrombin and fibrinogen to fibrin. Heparin increases the inhibitory action of antithrombin III (AT III) on clotting factors XIIa, XIa, IXa, Xa and thrombin.Initial IV bolus of 50 units/kg and then 100 units/kg IV q 4 hr, or 20,000 units/m 2 per 24 hr by continuous IV infusion.Heparin lock and extracorporeal dialysis: See manufacturer’s instructions.Clot prevention in blood samples: 70–150 units/10–20 mL of whole blood.Surgery of heart and blood vessels for patients undergoing total body perfusion: Not less than 150 units/kg guideline often used is 300 units/kg for procedures less than 60 min, 400 units/kg for longer procedures.Continuous IV infusion: Loading dose of 5,000 units and then 20,000–40,000 units/day.Intermittent IV: Initial dose of 10,000 units and then 5,000–10,000 units q 4–6 hr.Prophylaxis of postoperative thromboembolism: 5,000 units by deep subcutaneous injection 2 hr before surgery and q 8–12 hr thereafter for 7 days or until patient is fully ambulatory. ![]() For general anticoagulation: IV loading dose of 5,000 units and then 10,000–20,000 units subcutaneously followed by 8,000–10,000 units q 8 hr or 15,000–20,000 units q 12 hr. ![]() ![]() Subcutaneous (deep subcutaneous injection) The following are guidelines to dosage: ADULTS Dosage is adequate when WBCT = 2.5–3 times control-or aPTT = 1.5–2 times control value. Generic Name : heparin, heparin sodium injection, heparin sodium and 0.9% sodium chloride, heparin sodium lock flush solutionīrand Name: Hepalean (CAN), Heparin Leo (CAN), Hepalean-Lok (CAN), Heparin Lock Flush, Hep-Lock, Hep-Lock U/PĪvailable forms :Injection-1,000, 2,000, 2,500, 5,000, 7,500, 10,000, 12,500, 20,000, 40,000 units/mL also single-dose and unit-dose forms lock flush solution-10, 100 units/mL.ĭosages : Adjust dosage according to coagulation tests. ![]()
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